Reacción #9246

ord-8af57543031d410a83801cfb7baaad6c

Ecuación de reacción

CCNC(=O)Nc1nc2ccc(C(=O)CCN)cc2s1
1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea
CCN(CC)CC
triethylamine
O=C=Nc1ccccc1F
2-fluorophenyl isocyanate
→
CCNC(=O)Nc1nc2ccc(C(=O)CCNC(=O)Nc3ccccc3F)cc2s1
desired compound
Rendimiento 26.0%
CCNC(=O)Nc1nc2ccc(C(=O)CCNC(=O)Nc3ccccc3F)cc2s1
1-(6-(3-(2-Fluorophenyl)aminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea
Rendimiento 26.0%

Reactantes

CCNC(=O)Nc1nc2ccc(C(=O)CCN)cc2s1
1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea
CCN(CC)CC
triethylamine
O=C=Nc1ccccc1F
2-fluorophenyl isocyanate

Reactivos

Ninguno

Disolventes

CN(C)C=O
DMF

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroSimilar to the synthesis of Example 249
  2. 2
    Otrowas reacted

Procedimiento

Similar to the synthesis of Example 249, a mixture of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea, triethylamine and 2-fluorophenyl isocyanate in DMF was reacted to give the desired compound 0.022 g (26%). LC/MS 430.01 (M+1); LC retention time 2.89 min.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07091227B2uspto-grants-2006_08