Reacción #9237

ord-3b86cf3eeca34ce7947e49ad0db3feaf

Ecuación de reacción

CCNC(=O)Nc1nc2ccc(C(=O)CCN)cc2s1
1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea
CCN(CC)CC
triethylamine
[N-]=C=O
isocyanate
→
CCNC(=O)Nc1nc2ccc(C(=O)CCNC(=O)Nc3cccc(C)c3)cc2s1
desired compound
Rendimiento 25.0%
CCNC(=O)Nc1nc2ccc(C(=O)CCNC(=O)Nc3cccc(C)c3)cc2s1
(6-(3-(3-Methylphenyl)aminocarbonylamino-propanoyl)-2-benzothiazolyl)-3-ethylurea
Rendimiento 25.0%

Reactantes

CCNC(=O)Nc1nc2ccc(C(=O)CCN)cc2s1
1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea
CCN(CC)CC
triethylamine
[N-]=C=O
isocyanate

Reactivos

Ninguno

Disolventes

CN(C)C=O
DMF

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    OtroSimilar to the synthesis of Example 249
  2. 2
    Otrowas reacted

Procedimiento

Similar to the synthesis of Example 249, a mixture of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea, triethylamine and 3-methylphenhyl isocyanate in DMF was reacted to give the desired compound 0.021 g (25%). LC/MS 426.1 (M+1); LC retention time 2.94 min.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US07091227B2uspto-grants-2006_08