Reacción #92359

Ecuación de reacción

4-iodo-1H-pyrazole

K2CO3

bromocyclopentane

→

1-Cyclopentyl-4-iodo-1H-pyrazole

Rendimiento 89.5%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was quenched
2. 2
   Extracciónextracted as in Intermediate Example 5(a)
3. 3
   workup.DISTILLATIONThe solvent was distilled off
4. 4
   Otroto give the product in 89.5% yield
5. 5
   Otro263 [M+H]+ (rt: 1.57 min)

Procedimiento

To a solution of 4-iodo-1H-pyrazole (5 g, 25.78 mmol, 1.0 eq.) in DMF (25 ml) were added K2CO3 (8.908 g, 64.45 mmol, 2.5 eq.) and bromocyclopentane (4.96 g, 33.51 mmol, 1.3 eq.). The mixture was stirred at RT for 12 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to give the product in 89.5% yield. 1H NMR (300 MHz, CDCl3): δ 7.49 (s, 1H), 7.45 (s, 1H), 4.66-4.62 (m, 1H), 2.17-2.02 (m, 1H), 2.00-1.96 (m, 2H), 1.93-1.78 (m, 2H), 1.73-1.67 (m, 2H). LC-MS (ESI): Calculated mass: 262; Observed mass: 263 [M+H]+ (rt: 1.57 min).

Fuente