Reacción #9191

Ecuación de reacción

ethyl-2-amino-thiazole-5-carboxylate

di-t-butyldicarbonate

tetrahydrofuran

→

title compound

Rendimiento 70.0%

Ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate

Rendimiento 70.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was evaporated in vacuo
2. 2
   LavadoThe solid was washed with ether (10 mL, 3×)
3. 3
   Otrodried in vacuo

Procedimiento

A suspension of ethyl-2-amino-thiazole-5-carboxylate (972 mg, 6 mmol, B. Plouvler, C. Bailly, R. Houssin, j-P. Henlchart Heterocyles 32(4), 693–701, 1991 and H. J. Becker, J. de Jonge Rec. Trav. Chim, 61, 463, 1942), di-t-butyldicarbonate (1.94 g, 9 mmol) and 4-dimethylaminopyridine (73 mg, 0.6 mmol) in dry tetrahydrofuran (75 mL) was stirred under nitrogen for 24 h. The solvent was evaporated in vacuo. The residue was suspended in ether (50 mL). The solid was washed with ether (10 mL, 3×), and dried in vacuo to obtain the title compound (1.1 g, 70%).

Fuente