Reacción #91671

Ecuación de reacción

2-bromopyridin-3-ol

pyrrolidine

HCl

→

2-(pyrrolidin-1-yl)pyridin-3-ol

Rendimiento 41.3%

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with ethyl acetate and dichloromethane
2. 2
   SecadoThe obtained organic layer was dried over magnesium sulfate
3. 3
   Concentraciónconcentrated under reduced pressure
4. 4
   OtroThe concentrate was purified by column chromatography

Procedimiento

2-bromopyridin-3-ol (200 mg, 1.15 mmol) and pyrrolidine (184 mg, 2.58 mmol) were added in a reaction tube, followed by reacting in microwave at 120° C. for 20 minutes. The reaction mixture was added with 1 M HCl solution to neutralized, and extracted with ethyl acetate and dichloromethane. The obtained organic layer was dried over magnesium sulfate, and concentrated under reduced pressure. The concentrate was purified by column chromatography to obtain 2-(pyrrolidin-1-yl)pyridin-3-ol (78 mg, 41%).

Fuente