Reacción #91658

Ecuación de reacción

2-Bromopyridin-3-ol

3-thiophenyl boronic acid

sodium carbonate

→

2-(thiophene-3-yl)pyridin-3-ol

Rendimiento 48.6%

Disolventes

dimethoxyethane water

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter the completion of the reaction
2. 2
   Filtraciónthe reaction mixture was filtered
3. 3
   workup.ADDITIONThe filtrate was added with water
4. 4
   Extracciónextracted with ethyl acetate
5. 5
   SecadoThe obtained organic layer was dried over magnesium sulfate
6. 6
   Otropurified by column chromatography (ethyl acetate:hexane=1:3)

Procedimiento

2-Bromopyridin-3-ol (100 mg, 0.58 mmol), 3-thiophenyl boronic acid (88 mg, 0.69 mmol), sodium carbonate (184 mg, 2.07 mmol) and Pd2(dppf)2Cl2 (94 mg, 0.12 mmol) were dissolved in dimethoxyethane/water of 1 mL/1 mL, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The filtrate was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, and purified by column chromatography (ethyl acetate:hexane=1:3) to obtain 2-(thiophene-3-yl)pyridin-3-ol (50 mg, 48%).

Fuente