Reacción #91571

Ecuación de reacción

tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate

1-(4-Isopropylbenzyl)-5-(1H-pyrazol-4-yl)indoline

5-bromoindoline

1-(bromomethyl)-4-(tert-butyl)benzene

→

1-(4-(tert-butyl)benzyl)-5-(1H-pyrazol-4-yl)indoline

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofollowed by hydrolysis
2. 2
   Otrothe reaction conditions

Procedimiento

1-(4-Isopropylbenzyl)-5-(1H-pyrazol-4-yl)indoline, 50 can be prepared by alkylation of 5-bromoindoline, 22 with 1-(bromomethyl)-4-(tert-butyl)benzene using the conditions described in Example 7, part 1 followed by palladium catalyzed coupling of the alkylation product with tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate, 10 followed by hydrolysis using the reaction conditions described in Example 8.

Fuente