Reacción #915

Ecuación de reacción

2-bromo-N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-3-sulfonamide

TFA

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title compound

Rendimiento 21.4%

2-Bromo-1-methyl-1H-pyrrole-3-sulfonamide

Rendimiento 21.4%

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated in vacuo
2. 2
   workup.ADDITIONThree portions of diethyl ether were added to the crude residue
3. 3
   Otrowas removed by evaporation
4. 4
   Otroto remove residual TFA, which

Procedimiento

To a solution of 7.11 g (24 mmol) of 2-bromo-N-(1,1-dimethylethyl)-1-methyl-1H-pyrrole-3-sulfonamide in 50 mL methylene chloride under a nitrogen atmosphere was added 50 mL of TFA. The reaction mixture was allowed to stir at room temperature overnight ca. 16 hours. The reaction mixture was concentrated in vacuo. Three portions of diethyl ether were added to the crude residue and was removed by evaporation to remove residual TFA, which yielded 1.23 g of the title compound as a light brown solid.

Fuente