Reacción #91327
ord-e1a5247fbad64072b8ebb1caadebb01a
Ecuación de reacción
4-chloro-2-methylbenzylamine
3-fluoroisonicotinic acid
→
title compound
Rendimiento 45.0%
3-[(4-chloro-2-methylbenzyl)amino]pyridine-4-carboxylic acid
Rendimiento 45.0%
Reactivos
Ninguno
Condiciones de reacción
Condiciones detalladas
See reaction.notes.procedure_details.
Procedimiento
The title compound was prepared in 45% yield from 4-chloro-2-methylbenzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.50 (br s, 1H), 8.10 (s, 1H), 7.85 (d, 1H, J=5.0 Hz), 7.61 (br s, 1H), 7.59 (d, 1H, J=5.0 Hz), 7.31 (s, 1H), 7.19-7.25 (m, 2H), 4.52 (s, 2H), 2.34 (s, 3H). [M+H] calc'd for C14H13ClN2O2, 277, 279. found 277, 279.