Reacción #91325

ord-ee96d740cef84269aa7b3cfa1c069cd9

Ecuación de reacción

NCc1ccc(Cl)c(Cl)c1
3,4-dichlorobenzylamine
O=C(O)c1ccncc1F
3-fluoroisonicotinic acid
O=C(O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
title compound
Rendimiento 37.0%
O=C(O)c1ccncc1NCc1ccc(Cl)c(Cl)c1
3-[(3,4-dichlorobenzyl)amino]pyridine-4-carboxylic acid
Rendimiento 37.0%

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared in 37% yield from 3,4-dichlorobenzylamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 13.48 (br s, 1H), 8.10 (s, 1H), 7.84 (d, 1H, J=5.0 Hz), 7.57-7.65 (m, 3H), 7.35 (dd, 1H, J=8.3, 1.9 Hz), 4.59 (s, 2H). [M+H] calc'd for C13H10Cl2N2O2, 297, 299. found 297, 299.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09447045B2uspto-grants-2016_09