Reacción #91322

ord-d14444f7b0784a0ba0c3123c71a406c4

Ecuación de reacción

CC(C)Oc1ccc(CN)cc1
1-(4-isopropoxyphenyl)-methanamine
O=C(O)c1ccncc1F
3-fluoroisonicotinic acid
CC(C)Oc1ccc(CNc2cnccc2C(=O)O)cc1
title compound
Rendimiento 28.0%
CC(C)Oc1ccc(CNc2cnccc2C(=O)O)cc1
3-{[4-(propan-2-yloxy)benzyl]amino}pyridine-4-carboxylic acid
Rendimiento 28.0%

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound was prepared in 28% yield from 1-(4-isopropoxyphenyl)-methanamine and 3-fluoroisonicotinic acid according to the procedure for the preparation of Example 3. 1H NMR (400 MHz, DMSO-d6): δ 8.12 (s, 1H), 7.80 (d, 1H, J=5.0 Hz), 7.56 (d, 1H, J=5.0 Hz), 7.28 (d, 2H, J=8.0 Hz), 7.21 (d, 2H, J=8.0 Hz), 4.49 (s, 2H), 2.82-2.89 (m, 1H), 1.19 (d, 6H, J=4.5 Hz). [M+H] calc'd for C16H18N2O3, 287. found 287.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09447045B2uspto-grants-2016_09