Reacción #91269

Ecuación de reacción

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine

[2-(3-fluoro-4-hydroxy-phenyl)-cyclopropyl]-acetic acid methyl ester

→

title compound

Rendimiento 90.6%

{2-[4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-3-fluoro-phenyl]-cyclopropyl}-acetic acid

Rendimiento 90.6%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto react sequentially in the same manner as in Steps A and B of Example 1

Procedimiento

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine (0.026 g, 0.11 mmol) obtained in Step C of Preparation Example 27 and [2-(3-fluoro-4-hydroxy-phenyl)-cyclopropyl]-acetic acid methyl ester (0.026 g, 0.11 mmol) obtained in Step F of Preparation Example 53 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.040 g, 87%).

Fuente