Reacción #91260

Ecuación de reacción

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine

2-(3,5-difluoro-4-hydroxy-benzyl]-cyclopropane carboxylic acid ethyl ester

→

title compound

Rendimiento 88.2%

2-[4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-3,5-difluoro-benzyl]-cyclopropane carboxylic acid

Rendimiento 88.2%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto react sequentially in the same manner as in Steps A and B of Example 1

Procedimiento

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine (0.023 g, 0.10 mmol) obtained in Step C of Preparation Example 27 and 2-(3,5-difluoro-4-hydroxy-benzyl]-cyclopropane carboxylic acid ethyl ester (0.026 g, 0.10 mmol) obtained in Step D of Preparation Example 49 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (0.037 g, 88%).

Fuente