Reacción #91253

Ecuación de reacción

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine

2-(3-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester

→

title compound

Rendimiento 72.0%

2-[3-chloro-4-(6-cyclopentylsulfanyl-pyridin-2-ylmethoxy)-phenyl]-cyclopropane carboxylic acid

Rendimiento 72.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroto react sequentially in the same manner as in Steps A and B of Example 1

Procedimiento

2-Chloromethyl-6-cyclopentylsulfanyl-pyridine (42 mg, 0.18 mmol) obtained in Step C of Preparation Example 27 and 2-(3-chloro-4-hydroxy-phenyl)-cyclopropane carboxylic acid ethyl ester (49 mg, 0.20 mmol) obtained in Step B of Preparation Example 47 were used to react sequentially in the same manner as in Steps A and B of Example 1 to obtain the title compound (47 mg, 72%).

Fuente