Reacción #91161

Ecuación de reacción

6-mercapto-pyridine-2-carboxylic acid ethyl ester

Cs2CO3

bromo cyclobutane

→

title compound

Rendimiento 93.0%

6-cyclobutylsulfanyl-pyridine-2-carboxylic acid ethyl ester

Rendimiento 93.0%

Disolventes

CH3CN

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter the termination of the reaction
2. 2
   Filtraciónthe reactant was filtered
3. 3
   Concentraciónconcentrated under reduced pressure
4. 4
   Otropurified by column chromatography (eluent, EtOAc/Hex=1/5)

Procedimiento

After 6-mercapto-pyridine-2-carboxylic acid ethyl ester (0.40 g, 2.18 mmol) was dissolved in CH3CN (9 mL), Cs2CO3(2.667 g, 6.54 mmol) and bromo cyclobutane (0.385 mL, 3.27 mmol) were added thereto, and the mixture was stirred at 50° C. for 18 hours. After the termination of the reaction, the reactant was filtered, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (0.481 g, 92%).

Fuente