Reacción #91150

Ecuación de reacción

6-bromo-pyridine-2-carboxylic acid methyl ester

K2CO3

cyclohexanethiol

→

title compound

Rendimiento 46.4%

6-cyclohexylsulfanyl-pyridine-2-carboxylic acid methyl ester

Rendimiento 46.4%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter the termination of the reaction
2. 2
   Concentraciónthe reactant was concentrated under reduced pressure
3. 3
   Extracciónextracted with EtOAc
4. 4
   Otropurified by column chromatography (eluent, EtOAc/Hex=1/5)

Procedimiento

After 6-bromo-pyridine-2-carboxylic acid methyl ester (0.30 g, 1.39 mmol) was dissolved in DMF (4 mL), K2CO3(0.575 g, 4.16 mmol) and cyclohexanethiol (0.25 mL, 2.08 mmol) were added thereto in turn, and the mixture was stirred at 70° C. for 18 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure, extracted with EtOAc, and purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (0.162 g, 46%).

Fuente