Reacción #91127

Ecuación de reacción

NaOH

2-mercapto-nicotinic acid

1-Iodobutane

→

title compound

Rendimiento 100.2%

2-butylsulfanyl-nicotinic acid

Rendimiento 100.2%

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe mixture was stirred
2. 2
   Temperaturaunder reflux at 80° C. for 16 hours
3. 3
   ConcentraciónThe reactant was concentrated under reduced pressure, and 6 M HCl aqueous solution
4. 4
   workup.ADDITIONwas added
5. 5
   FiltraciónThe resulting precipitate was filtered
6. 6
   Otrodried

Procedimiento

After MeOH (20 mL) was added to 2-mercapto-nicotinic acid (1 g, 6 mmol), the mixture was cooled to 0° C., and 6 M NaOH aqueous solution (3.2 mL) was added slowly thereto. The reactant was stirred at 0° C. for 30 minutes. 1-Iodobutane (0.74 mL, 6 mmol) was added to the reactant, and the mixture was stirred under reflux at 80° C. for 16 hours. The reactant was concentrated under reduced pressure, and 6 M HCl aqueous solution was added thereto to adjust the pH of the solution to 7. The resulting precipitate was filtered and dried to obtain the title compound (1.27 g, 93%).

Fuente