Reacción #90993

Ecuación de reacción

methyl 3,5-dichloro-4-hydroxybenzoate

Methyl 3,5-dichloro-4-hydroxybenzoate

benzyl bromide

→

methyl 4-(benzyloxy)-3,5-dichlorobenzoate

Rendimiento 120.2%

Methyl 4-(benzyloxy)-3,5-dichlorobenzoate

Rendimiento 120.2%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe crude product was partially purified by silica gel chromatography (330 g, 0-10% EtOAc/isohexane)
2. 2
   Otroto afford a white solid
3. 3
   OtroThe material was used in the next step without further purification

Procedimiento

Crude methyl 4-(benzyloxy)-3,5-dichlorobenzoate (2) (16.9 g) was prepared from methyl 3,5-dichloro-4-hydroxybenzoate (1) (10 g, 45.2 mmol) and benzyl bromide (15.5 g, 90 mmol) using a procedure essentially the same as in Step (i) for AAA-001, except that the mixture was stirred at RT for 18 h. The crude product was partially purified by silica gel chromatography (330 g, 0-10% EtOAc/isohexane) to afford a white solid. The material was used in the next step without further purification.

Fuente