Reacción #90395

Ecuación de reacción

VII

(E)-N′-(2,7-dicyanobenzo[d]thiazol-6-yl)-N,N-dimethylformimidamide

2,3-dihydro-1-benzofuran-5-amine

KBr

→

9-(2,3-Dihydrobenzofuran-5-ylamino)thiazolo[5,4-f]quinazoline-2-carbonitrile

Rendimiento 95.0%

Disolventes

EtOAc

Condiciones de reacción

Procedimiento

Prepared from VII and 2,3-dihydro-1-benzofuran-5-amine. Flash chromatography eluent (EtOAc). Yield: 95%; yellow solid; mp 216° C.; IR (KBr) νmax/cm−1 2894, 2853, 2228, 1643, 1609, 1579, 1484, 1467, 1376, 1353, 1306, 1269, 1219, 1192, 1164, 1123, 978, 941, 881, 814; 1H NMR (300 MHz, DMSO-d6) δ 8.49 (d, 1H, J=8.7 Hz), 8.10 (s, 1H), 7.75 (d, 1H, J=8.7 Hz), 7.22 (m, 1H), 7.04 (s, 1H), 6.78 (m, 1H), 4.53 (t, 2H, J=8.7 Hz), 3.20 (t, 1H, J=8.7 Hz); HRMS calcd for C18H12N5OS (M+H+): 346.0763, found 346.0762.

Fuente