Reacción #9017

Ecuación de reacción

4-(bromomethyl)-2-methoxybenzonitrile

(1-tert-butoxycarbonyl-1H-Benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydro-quinolin-8-yl)-amine

N,N-diisopropylethylamine

→

white foam

Rendimiento 68.8%

(4-Aminomethyl-3-methoxy-benzyl)-(1H-benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydro-quinolin-8-yl)-amine

Rendimiento 68.8%

Disolventes

CH3CN

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe mixture was concentrated
2. 2
   Otrothe residue was partitioned between CH2Cl2 (40 mL) and brine (10 mL)
3. 3
   OtroThe phases were separated
4. 4
   Extracciónthe aqueous phase was extracted with CH2Cl2 (3×10 mL)
5. 5
   SecadoThe combined organic extracts were dried (Na2SO4)
6. 6
   Concentraciónconcentrated
7. 7
   OtroPurification of the crude material by column chromatography on silica gel (20:1 CH2Cl2—CH3OH)

Procedimiento

To a solution of (1-tert-butoxycarbonyl-1H-Benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydro-quinolin-8-yl)-amine (0.386 g, 1.02 mmol) in CH3CN (10 mL) was added N,N-diisopropylethylamine (0.35 mL, 2.00 mmol) followed by of 4-(bromomethyl)-2-methoxybenzonitrile (0.363 g, 1.60 mmol). The resultant mixture was heated to 60° C. for 15 hours then cooled to room temperature. The mixture was concentrated and the residue was partitioned between CH2Cl2 (40 mL) and brine (10 mL). The phases were separated and the aqueous phase was extracted with CH2Cl2 (3×10 mL). The combined organic extracts were dried (Na2SO4) and concentrated. Purification of the crude material by column chromatography on silica gel (20:1 CH2Cl2—CH3OH) followed by radial chromatography on silica gel (2 mm plate, 2:1 hexanes-EtOAc) provided 0.30 g (56%) of a white foam.

Fuente