Reacción #89910

Ecuación de reacción

2-(3-nitrophenyl)-4-oxo-3,4-dihydroquinazolin-6-yl acetate

SOCl2

DMF

→

4-chloro-2-(3-nitrophenyl)quinazolin-6-yl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was refluxed for 2.5 h, upon which the volatiles
2. 2
   Otrowere removed in vacuo
3. 3
   Lavadowashed
4. 4
   SecadoThe organic layer was dried (Na2SO4)
5. 5
   Filtraciónfiltered
6. 6
   Concentraciónconcentrated in vacuo

Procedimiento

A suspension of 2-(3-nitrophenyl)-4-oxo-3,4-dihydroquinazolin-6-yl acetate (3.30 g, 10.1 mmol) in SOCl2 (65 mL) was added DMF (2 mL). The mixture was refluxed for 2.5 h, upon which the volatiles were removed in vacuo. The residue was taken up in CHCl3 (450 mL) and washed with sat NaHCO3 (200 ml) and water (200 mL). The organic layer was dried (Na2SO4), filtered and concentrated in vacuo to give the product 4-chloro-2-(3-nitrophenyl)quinazolin-6-yl acetate (3.53 g, 10.3 mmol). HPLC retention time 9.748 min.

Fuente