Reacción #89756

Ecuación de reacción

methyl chloroformate

methyl(2S,3S,5S)-5-tert-butoxy-2-[(4-phenylpiperazin-1-yl)carbonyl]piperidine-3-carboxylate

methylene chloride

→

dimethyl(2S,3S,5S)-5-tert-butoxy-2-[(4-phenylpiperazin-1-yl)carbonyl]piperidine-1,3-dicarboxylate

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter quenched with aq. sodium bicaronate
2. 2
   Extracciónthe reaction was extracted with ethyl acetate
3. 3
   LavadoThe combined organic layers were washed with brine
4. 4
   Otrodried
5. 5
   Concentraciónconcentrated
6. 6
   Otroto dry

Procedimiento

To a mixture of methyl(2S,3S,5S)-5-tert-butoxy-2-[(4-phenylpiperazin-1-yl)carbonyl]piperidine-3-carboxylate (0.03345 g, 8.290E-5 mol) and 4-dimethylaminopyridine (0.0152 g, 0.000124 mol) in methylene chloride (1.50 mL, 0.0234 mol) was added methyl chloroformate (0.00833 mL, 0.000108 mol). The reaction was stirred at rt overnight. After quenched with aq. sodium bicaronate, the reaction was extracted with ethyl acetate. The combined organic layers were washed with brine, dried, concentrated to dry. The resulting residue was used directly in next step. MS (ESI): (M+H)+=462.2.

Fuente