Reacción #89604

Ecuación de reacción

3,4-Dimethyl-pentanal

Dibutylamine

acetic acid

formaldehyde

→

3,4-dimethyl-2-methylene-pentanal

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITaged for another hour
2. 2
   TemperaturaThe reaction mixture was cooled down
3. 3
   LavadoThe reaction mixture was sequentially washed with water (2 L), sodium carbonate solution (1 L), and brine (1 L)

Procedimiento

Dibutylamine (34 g), acetic acid (15.78 g), and formaldehyde (230 g) were charged to a reaction flask and heated to 70° C. 3,4-Dimethyl-pentanal (500 g) was fed over 2 hours and aged for another hour. The reaction mixture was cooled down and toluene (200 mL) was added. The reaction mixture was sequentially washed with water (2 L), sodium carbonate solution (1 L), and brine (1 L) to provide the crude product 3,4-dimethyl-2-methylene-pentanal.

Fuente