Reacción #8958

Ecuación de reacción

methyliodide

Sodium hydride

2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine

water

→

desired compound

4-(1,2-Dimethyl-1H-imidazol-4-ylethynyl)-2-methyl-pyridine

Disolventes

THF

THF

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITwas continued overnight
3. 3
   Extracciónextracted three times with ethyl acetate (70 mL each)
4. 4
   SecadoThe combined organic extracts were dried with sodium sulfate
5. 5
   Filtraciónfiltered
6. 6
   Otroevaporated
7. 7
   OtroThe crude product was purified by flash chromatography on silica gel (dichloromethane/methanol 100:0->90:10 gradient)
8. 8
   workup.ADDITIONa mixture of two regioisomers
9. 9
   Otrowas obtained
10. 10
    OtroThis mixture could be separated by HPLC (chiralpak AD, heptane/ethanol 4/1)

Procedimiento

Sodium hydride (76 mg, 55%, 1.57 mmol) was suspended in 2 mL of dry THF. A solution of 2-methyl-4-(2-methyl-1H-imidazol-4-ylethynyl)-pyridine (150 mg, 0.76 mmol) in 8 mL of dry THF was added and the reaction mixture was stirred at room temperature for 30 min. A solution of methyliodide (142 mg, 1.00 mmol) in 1 mL of dry THF was added and stirring was continued overnight. The reaction mixture was poured into 70 mL of water and extracted three times with ethyl acetate (70 mL each). The combined organic extracts were dried with sodium sulfate, filtered and evaporated. The crude product was purified by flash chromatography on silica gel (dichloromethane/methanol 100:0->90:10 gradient) and a mixture of two regioisomers was obtained. This mixture could be separated by HPLC (chiralpak AD, heptane/ethanol 4/1) and the desired compound was obtained as a white solid (40 mg, 25%), MS: m/e=212.2 (M+H+).

Fuente