Reacción #89491

Ecuación de reacción

((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone

2-fluoro-5-(trifluoromethyl)pyridine

→

title compound

(4,5-Difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)amino)methyl)piperidin-1-yl)methanone

Condiciones de reacción

Procedimiento

The title compound was prepared following the same general protocol as described for Example A1 using ((2S,3R)-2-(aminomethyl)-3-methylpiperidin-1-yl)(4,5-difluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone and 2-fluoro-5-(trifluoromethyl)pyridine. ESI-MS (m/z): 481 [M+1]+. 1H NMR (300 MHz, DMSO-d6) δ 8.30-6.50 (m, 8H), 4.80-2.70 (m, 5H), 1.90-0.65 (m, 8H).

Fuente