Reacción #8925

Ecuación de reacción

benzyl 3-chlorosulfonyl-2(R)-methylpropionate

ammonia

→

benzyl 3-aminosulfonyl-2(R)-methylpropionate

Disolventes

CH2Cl2

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroA 100 mL round bottom flask equipped with magnetic stir bar
2. 2
   TemperaturaAfter 20 minutes the reaction was warmed to room temperature
3. 3
   Concentraciónconcentrated in vacuo
4. 4
   Otroto afford a white solid
5. 5
   Filtraciónfiltered
6. 6
   Otroto remove inorganic salts
7. 7
   Concentraciónconcentrated in vacuo

Procedimiento

A 100 mL round bottom flask equipped with magnetic stir bar was charged with 1.22 g of benzyl 3-chlorosulfonyl-2(R)-methylpropionate in 15 mL CH2Cl2 and cooled to −78° C. To this solution was added to 10 mL of liquid ammonia at −78° C. After 20 minutes the reaction was warmed to room temperature, concentrated in vacuo to afford a white solid. The solid was slurried in ethyl acetate, filtered to remove inorganic salts and concentrated in vacuo to afford 1.08 g of benzyl 3-aminosulfonyl-2(R)-methylpropionate as a clear yellow oil. The crude product was used without further purification.

Fuente