Reacción #88880

Ecuación de reacción

2-(1,3-oxazol-5-yl)benzoic acid

4-benzyl-4-hydroxypiperidine

1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

1-hydroxybenzotriazole

→

title compound

Rendimiento 48.7%

(4-benzyl-4-hydroxypiperidin-1-yl)(2-(1,3-oxazol-5-yl)phenyl)methanone

Rendimiento 48.7%

Disolventes

water

DMF

triethylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture was extracted with ethyl acetate
2. 2
   LavadoThe extract was washed with water and saturated brine
3. 3
   Secadodried over anhydrous sodium sulfate
4. 4
   Otrothe solvent was evaporated under reduced pressure
5. 5
   OtroThe residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether)

Procedimiento

A suspension of 2-(1,3-oxazol-5-yl)benzoic acid (0.30 g), 4-benzyl-4-hydroxypiperidine (0.36 g), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.46 g), 1-hydroxybenzotriazole (0.40 g) and triethylamine (0.40 g) in DMF (3 mL) was stirred at room temperature for 16 hr. The reaction mixture was diluted with water, and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/petroleum ether) to give the title compound (0.28 g).

Fuente