Reacción #88710

Ecuación de reacción

5-((4-chlorophenyl)(hydroxy)methyl)-1-methyl-3-(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)-6-((5-(trifluoromethyl)pyridin-3-yl)oxy)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

→

3-(5-(4-chlorobenzyl)-1-methyl-2,4-dioxo-6-((5-(trifluoromethyl)pyridin-3-yl)oxy)-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)propyl formate

Rendimiento 29.8%

Disolventes

HCOOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooled to RT
2. 2
   Filtraciónfiltered
3. 3
   ConcentraciónThe filtrate was concentrated to a residue which
4. 4
   Otrowas purified by Prep TLC
5. 5
   Lavadoeluted with PE/EA (1:1)

Procedimiento

To a solution of 5-((4-chlorophenyl)(hydroxy)methyl)-1-methyl-3-(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)-6-((5-(trifluoromethyl)pyridin-3-yl)oxy)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (172 mg, 0.277 mmol) in HCOOH (5 mL) was added Zn dust (88.5 mg, 1.385 mmol) at 20° C. The reaction was heated at 50° C. for 2 h, cooled to RT and filtered. The filtrate was concentrated to a residue which was purified by Prep TLC eluted with PE/EA (1:1) to give 3-(5-(4-chlorobenzyl)-1-methyl-2,4-dioxo-6-((5-(trifluoromethyl)pyridin-3-yl)oxy)-1,2-dihydropyrido[2,3-d]pyrimidin-3(4H)-yl)propyl formate (45.3 mg, 29.8% yield) as an oil. LCMS: MH+ 549 and TR=1.471 min.

Fuente