Reacción #88664

Ecuación de reacción

2-(5-chloropyridin-2-yl)furo[3,2-c]pyridin-4(5H)-one

2-cyclopropyl-6-iodo-3-methylimidazo[1,2-a]pyridine

N,N′-dimethylethylenediamine

potassium carbonate

→

title compound

Rendimiento 2.0%

2-(5-Chloropyridin-2-yl)-5-(2-cyclopropyl-3-methylimidazo[1,2-a]pyridin-6-yl)furo[3,2-c]pyridin-4(5H)-one

Rendimiento 2.0%

Disolventes

DMSO

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction mixture was purified by silica gel column chromatography (NH, ethyl acetate/hexane)
2. 2
   Lavadothe obtained solid was washed with ethyl acetate

Procedimiento

A mixture of 2-(5-chloropyridin-2-yl)furo[3,2-c]pyridin-4(5H)-one (69.0 mg), 2-cyclopropyl-6-iodo-3-methylimidazo[1,2-a]pyridine (100 mg), N,N′-dimethylethylenediamine (0.030 mL), copper(I) iodide (53.3 mg), potassium carbonate (116 mg) and DMSO (3.0 mL) was heated at 220° C. for 1 hr under microwave irradiation. The reaction mixture was purified by silica gel column chromatography (NH, ethyl acetate/hexane), and the obtained solid was washed with ethyl acetate to give the title compound (2.30 mg) as a pale red solid.

Fuente