Reacción #88392

Ecuación de reacción

2,6-difluoro-3-nitro-benzoyl chloride

5-iodo-1H-pyrrolo[2,3-b]pyridine

aluminum trichloride

→

desired compound

Rendimiento 60.2%

(2,6-difluoro-3-nitro-phenyl)-(5-iodo-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanone

Rendimiento 60.2%

Disolventes

nitromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONis added
2. 2
   TemperaturaThe reaction is heated at 45° C. for 93 hours
3. 3
   Otroquenched with addition of methanol
4. 4
   FiltraciónThe resulting precipitate is collected by filtration

Procedimiento

In a reaction vial, 5-iodo-1H-pyrrolo[2,3-b]pyridine (43, 1.00 g, 4.10 mmol) is mixed with 22 mL of nitromethane and aluminum trichloride (3.28 g, 24.6 mmol) is added. The reaction is stirred at room temperature for 1 hour and 2,6-difluoro-3-nitro-benzoyl chloride (44, 1.36 g, 6.15 mmol) is added. The reaction is heated at 45° C. for 93 hours, then quenched with addition of methanol. The resulting precipitate is collected by filtration to provide the desired compound (45, 1.06 g).

Fuente