Reacción #88217

Ecuación de reacción

2-fluoro-4-methylsulfonyl-aniline

KOAc

Br2

→

desired product

2-bromo-6-fluoro-4-methanesulfonyl-phenylamine

Disolventes

AcOH

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was cooled to 0° C.
2. 2
   workup.STIRRINGThe mixture was stirred for 30 min at 0° C
3. 3
   ConcentraciónThe mixture was concentrated
4. 4
   LavadoThe organic mixture was washed (sat. NaHCO3, sat. Na2S2O3)
5. 5
   Secadodried (Na2SO4)
6. 6
   Concentraciónconcentrated

Procedimiento

A mixture of 2-fluoro-4-methylsulfonyl-aniline (22.76 mmol) and KOAc (22.7 mmol) in AcOH was stirred at room temperature. The mixture was cooled to 0° C. and Br2 (22.7 mmol) was added dropwise. The mixture was stirred for 30 min at 0° C. The mixture was concentrated and the residue was taken up in EtOAc. The organic mixture was washed (sat. NaHCO3, sat. Na2S2O3), dried (Na2SO4) and concentrated to yield the desired product.

Fuente