Reacción #88122

ord-3427a8f1543647a382dd529af7ab6165

Ecuación de reacción

O=[N+]([O-])c1ccc(-c2ccnn2-c2ccc(F)cc2F)cc1
1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole
O=[N+]([O-])c1ccc(-c2ccnn2-c2ccc(F)cc2F)cc1
intermediate I
O=[N+]([O-])c1ccc(-c2ccnn2-c2ccc(F)cc2F)cc1
1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole
N#CCc1ccc(F)cc1
2-(4-fluoro-phenyl)-acetonitrile
Fc1ccc(-c2onc3ccc(-c4ccnn4-c4ccc(F)cc4F)cc23)cc1
title compound
Fc1ccc(-c2onc3ccc(-c4ccnn4-c4ccc(F)cc4F)cc23)cc1
5-[2-(2,4-Difluoro-phenyl)-2H-pyrazol-3-yl]-3-(4-fluoro-phenyl)-benzo[c]isoxazole

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound, light grey solid (22 mg, 17%), MS (ISP) m/z=392.2 [(M+H)+], mp 149° C., was prepared in accordance with the general method of example 1 from 1-(2,4-difluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate I) (100 mg, 353 μmol) and commercially available 2-(4-fluoro-phenyl)-acetonitrile.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09440962B2uspto-grants-2016_09