Reacción #88119

ord-6e2a579562844b8e857c1de655931736

Ecuación de reacción

O=[N+]([O-])c1ccc(-c2ccnn2-c2ccc(Cl)cc2)cc1
1-(4-chloro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole
O=[N+]([O-])c1ccc(-c2ccnn2-c2ccc(Cl)cc2)cc1
intermediate H
O=[N+]([O-])c1ccc(-c2ccnn2-c2ccc(Cl)cc2)cc1
1-(4-chloro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole
N#CCc1ccc(F)cc1
2-(4-fluoro-phenyl)-acetonitrile
Fc1ccc(-c2onc3ccc(-c4ccnn4-c4ccc(Cl)cc4)cc23)cc1
title compound
Fc1ccc(-c2onc3ccc(-c4ccnn4-c4ccc(Cl)cc4)cc23)cc1
5-[2-(4-Chloro-phenyl)-2H-pyrazol-3-yl]-3-(4-fluoro-phenyl)-benzo[c]isoxazole

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound, yellow solid (28 mg, 22%), MS (ISP) m/z=390.2 [(M+H)+], mp 154° C., was prepared in accordance with the general method of example 1 from 1-(4-chloro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate H) (100 mg, 353 μmol) and commercially available 2-(4-fluoro-phenyl)-acetonitrile.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09440962B2uspto-grants-2016_09