Reacción #88114

ord-6819518e924147a884fd567ffba2a050

Ecuación de reacción

COc1ccc(-n2nccc2-c2ccc([N+](=O)[O-])cc2)cc1
1-(4-methoxy-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole
COc1ccc(-n2nccc2-c2ccc([N+](=O)[O-])cc2)cc1
intermediate G
COc1ccc(-n2nccc2-c2ccc([N+](=O)[O-])cc2)cc1
1-(4-methoxy-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole
N#CCc1ccc(F)cc1
2-(4-fluoro-phenyl)-acetonitrile
COc1ccc(-n2nccc2-c2ccc3noc(-c4ccc(F)cc4)c3c2)cc1
title compound
COc1ccc(-n2nccc2-c2ccc3noc(-c4ccc(F)cc4)c3c2)cc1
3-(4-Fluoro-phenyl)-5-[2-(4-methoxy-phenyl)-2H-pyrazol-3-yl]-benzo[c]isoxazole

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound, light green solid (51 mg, 39%), MS (ISP) m/z=386.2 [(M+H)+], mp 179° C., was prepared in accordance with the general method of example 1 from 1-(4-methoxy-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate G) (100 mg, 353 μmol) and commercially available 2-(4-fluoro-phenyl)-acetonitrile.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09440962B2uspto-grants-2016_09