Reacción #88108

ord-660f030524904b4982d3f5c31ee5cdd3

Ecuación de reacción

Cc1ccc(-n2nccc2-c2ccc([N+](=O)[O-])cc2)cc1
5-(4-nitro-phenyl)-1 p-tolyl-1H-pyrazole
Cc1ccc(-n2nccc2-c2ccc([N+](=O)[O-])cc2)cc1
intermediate E
Cc1ccc(-n2nccc2-c2ccc([N+](=O)[O-])cc2)cc1
5-(4-nitro-phenyl)-1 p-tolyl-1H-pyrazole
N#CCc1ccc(F)cc1
2-(4-fluoro-phenyl)-acetonitrile
Cc1ccc(-n2nccc2-c2ccc3noc(-c4ccc(F)cc4)c3c2)cc1
title compound
Cc1ccc(-n2nccc2-c2ccc3noc(-c4ccc(F)cc4)c3c2)cc1
3-(4-Fluoro-phenyl)-5-(2-p-tolyl-2H-pyrazol-3-yl)-benzo[c]isoxazole

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

The title compound, light grey solid (50 mg, 38%), MS (ISP) m/z=370.2 [(M+H)+], mp 173° C., was prepared in accordance with the general method of example 1 from 5-(4-nitro-phenyl)-1 p-tolyl-1H-pyrazole (intermediate E) (100 mg, 353 μmol) and commercially available 2-(4-fluoro-phenyl)-acetonitrile.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US09440962B2uspto-grants-2016_09