Reacción #88012

Ecuación de reacción

methyl 3-(chlorosulfonyl)thiophene-2-carboxylate

THF

methanamine

→

methyl 3-(N-methylsulfamoyl)thiophene-2-carboxylate

Disolventes

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was partitioned between 2N HCl and DCM
2. 2
   Extracciónthe aqueous phase was extracted with DCM
3. 3
   SecadoThe combined organic layers were dried over sodium sulfate
4. 4
   Otrothe solvent was removed

Procedimiento

To a solution of methyl 3-(chlorosulfonyl)thiophene-2-carboxylate (500 mg, 2.077 mmol) in DCM (20 ml), methanamine 2N solution in THF (4.155 ml, 8.31 mmol) was added and the reaction was stirred for 1 hour at RT. The mixture was partitioned between 2N HCl and DCM and the aqueous phase was extracted with DCM. The combined organic layers were dried over sodium sulfate and the solvent was removed affording methyl 3-(N-methylsulfamoyl)thiophene-2-carboxylate (Int. 32) (430 mg, 1.828 mmol, MS/ESI+235.8 [MH]+).

Fuente