Reacción #87602

Ecuación de reacción

2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid

HCl

→

5-(aminomethyl)-2-chlorobenzoic acid hydrochloride

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction mixture was refluxed for 18 h
2. 2
   ConcentraciónThe reaction mixture was concentrated
3. 3
   Otrocrude reaction mixture

Procedimiento

To a solution of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid (step-1 of Intermediate-26, 10.0 g, 35.50 mmol) in methanol (100 mL) was added conc. HCl (10 mL). The reaction mixture was refluxed for 18 h. The reaction mixture was concentrated and crude reaction mixture was used for next step.

Fuente