Reacción #8758

Ecuación de reacción

3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole

potassium carbonate

3,4-dichlorobenzylamine

→

title compound

(3,4-dichloro-benzyl)-[2-(3-thieno[2,3-d]isoxazol-3-yl-phenoxy)-ethyl]-amine

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadois eluted
2. 2
   workup.ADDITIONa graded solvent mixture of 40% ethyl acetate in heptane

Procedimiento

The title compound is prepared from 3-[3-(2-bromo-ethoxy)-phenyl]-thieno[2,3-d]isoxazole, potassium carbonate, 3,4-dichlorobenzylamine and acetonitrile essentially as described above in example 18 except that the column is eluted using a graded solvent mixture of 40% ethyl acetate in heptane, to 100% ethyl acetate. Purity by LC/MS (APCI)=100%, [M+H]+=419.

Fuente