Reacción #87385

Ecuación de reacción

1-Amino-2-methylpropan-2-ol hydrochloride

Triethylamine

2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)-pyrimidine

→

title compound

Rendimiento 32.0%

1-(2-Chloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-ylamino)-2-methylpropan-2-ol

Rendimiento 32.0%

Disolventes

acetonitrile

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe suspension was filtered
2. 2
   OtroThe mixture was purified by preparative HPLC

Procedimiento

1-Amino-2-methylpropan-2-ol hydrochloride (221 mg, 1.76 mmol) was suspended in MeOH (2 mL). Triethylamine (0.147 mL, 1.06 mmol) was added and the suspension was filtered. The filtrate was added to an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)-pyrimidine (92 mg, 0.35 mmol) in acetonitrile (2 mL). The mixture was stirred for 1 h at rt. The mixture was purified by preparative HPLC to give the title compound (35 mg, 32%).

Fuente