Reacción #87383

Ecuación de reacción

cyclopropanamine

2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine

→

title compound

Rendimiento 57.0%

2-Chloro-N-cyclopropyl-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine

Rendimiento 57.0%

Disolventes

MeOH

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was purified by preparative HPLC
2. 2
   Otroyielding

Procedimiento

A solution of cyclopropanamine (68 mg, 1.20 mmol) in MeOH (2 mL) was added dropwise to an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (104 mg, 0.40 mmol) in acetonitrile (2 mL). The mixture was stirred at rt overnight. The mixture was purified by preparative HPLC yielding to give the title compound (64 mg, 57%).

Fuente