Reacción #87376

Ecuación de reacción

Chloroform

Sodium borohydride

2-Chloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine-4-carbaldehyde

Acetone

→

title compound

Rendimiento 58.0%

(2-Chloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-yl)methanol

Rendimiento 58.0%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGmixture was stirred for 10 min
2. 2
   Filtraciónthe mixture was filtered through a pad of silica
3. 3
   OtroThe solvents were evaporated
4. 4
   Otrothe residue was purified by column chromatography on silica eluting with a gradient of methanol in DCM

Procedimiento

2-Chloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine-4-carbaldehyde (0.6 g, 2.36 mmol) was dissolved in ethanol (20 mL). Sodium borohydride (0.134 g, 3.54 mmol) was added and the mixture was stirred at rt for 10 min. Acetone (5 mL) was added and mixture was stirred for 10 min. Chloroform (20 mL) was added and the mixture was filtered through a pad of silica. The solvents were evaporated and the residue was purified by column chromatography on silica eluting with a gradient of methanol in DCM to give the title compound 0.35 g (58%).

Fuente