Reacción #87369

Ecuación de reacción

Water

4,4-difluoropiperidine

sodium methoxide

2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine

→

title compound

2-Chloro-4-(4,4-difluoropiperidin-1-yl)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine

Disolventes

DMF

acetonitrile

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONadded
2. 2
   Otrothe residue was purified by preparative HPLC

Procedimiento

To an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (0.120 g, 0.46 mmol) in acetonitrile (2 mL) was a solution of 4,4-difluoropiperidine (0.217 g, 1.38 mmol) and sodium methoxide (30 wt % in methanol, 0.188 mL, 1.01 mmol) in MeOH (2 mL) added. The reaction was stirred at 0° C. for 2 hours. Water and DMF was added and the residue was purified by preparative HPLC to give the title compound as a dry film (0.110 g, 69%).

Fuente