Reacción #87364

Ecuación de reacción

2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine

benzylmethylamine

acetonitrile

→

N-Benzyl-2-chloro-N-methyl-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONadded
2. 2
   OtroThe solvent was evaporated
3. 3
   OtroThe mixture was purified by preparative HPLC the title compound (194 mg, 73%)

Procedimiento

To a solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (200 mg, 0.77 mmol) in acetonitrile (3 mL) was benzylmethylamine (0.296 mL, 2.30 mmol) added. The reaction was stirred at ambient temperature for 30 minutes. The solvent was evaporated. The mixture was purified by preparative HPLC the title compound (194 mg, 73%).

Fuente