Reacción #87347

Ecuación de reacción

isopropylamine

2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine

→

title compound

Rendimiento 56.0%

2-Chloro-N-isopropyl-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-amine

Rendimiento 56.0%

Disolventes

methanol

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe mixture was purified by preparative HPLC

Procedimiento

A solution of isopropylamine (0.102 mL, 1.20 mmol) in methanol (2 mL) was added dropwise to an ice-cold solution of 2,4-dichloro-6-((2,2,2-trifluoroethoxy)methyl)pyrimidine (104 mg, 0.40 mmol) in acetonitrile (2.0 mL). The reaction mixture was stirred overnight at rt. The mixture was purified by preparative HPLC yielding the title compound 63 mg (56%).

Fuente