Reacción #8708

Ecuación de reacción

4,6-dichloro-5-(4-chlorophenyl)pyrimidine

2-thiophen-2-yl-ethanesulfonic acid amide potassium salt

Hunig's base

→

2-thiophen-2-yl-ethanesulfonic acid [6-chloro-5-(4-chloro-phenyl)-pyrimidin-4-yl]-amide

Rendimiento 68.7%

Disolventes

DMSO

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted twice with diethyl ether
2. 2
   OtroThe precipitate was collected
3. 3
   Lavadowashed with water and diethyl ether
4. 4
   Otrodried

Procedimiento

A solution of 4,6-dichloro-5-(4-chlorophenyl)pyrimidine (848 mg), 2-thiophen-2-yl-ethanesulfonic acid amide potassium salt (1.5 g, Referential Example 14) and Hunig's base (1 ml) in DMSO (20 ml) was stirred at rt for 24 h before it was diluted with water (200 ml) and extracted twice with diethyl ether. The aqueous layer was acidified with acetic acid. The precipitate was collected, washed with water and diethyl ether and dried to give 2-thiophen-2-yl-ethanesulfonic acid [6-chloro-5-(4-chloro-phenyl)-pyrimidin-4-yl]-amide (930 mg) as a beige powder. LC-MS: tR=5.01 min, [M+1]+=413.49, [M−1]−=411.93.

Fuente