Reacción #87003

Ecuación de reacción

N,N-diisopropylethylamine

2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride

1-(3-fluoro-4-methoxyphenyl)-2-oxopyrrolidine-3-carboxylic acid

HATU

→

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-1-(3-fluoro-4-methoxyphenyl)-2-oxopyrrolidine-3-carboxamide

Rendimiento 40.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThis compound was prepared
2. 2
   OtroThe crude material was purified by flash chromatography on silica gel (eluent: 2 to 25% of ethyl acetate in dichloromethane)

Procedimiento

This compound was prepared according to method A with 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.100 g; 0.424 mmol), 1-(3-fluoro-4-methoxyphenyl)-2-oxopyrrolidine-3-carboxylic acid (0.113 g; 0.445 mmol), HATU (0.166 g; 0.437 mmol) and N,N-diisopropylethylamine (0.186 mL; 1.06 mmol) in DMF (5 mL). The crude material was purified by flash chromatography on silica gel (eluent: 2 to 25% of ethyl acetate in dichloromethane) to give 0.072 g (40%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-1-(3-fluoro-4-methoxyphenyl)-2-oxopyrrolidine-3-carboxamide as a white solid.

Fuente