Reacción #86996

Ecuación de reacción

1-(4-acetylphenyl)-2-oxopyrrolidine-3-carboxylic acid

2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride

PyBOP

N,N diisopropylethylamine

→

1-(4-acetylphenyl)-N-(2-(5-chloro-1H-indol-3-yl)ethyl)-2-oxopyrrolidine-3-carboxamide

Disolventes

DMF

Dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThis compound was prepared
2. 2
   Otroto precipitate 1-(4-acetylphenyl)-N-(2-(5-chloro-1H-indol-3-yl)ethyl)-2-oxopyrrolidine-3-carboxamide 0.105 g (29%) as a solid

Procedimiento

This compound was prepared according to method E with 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.200 g; 0.865 mmol), PyBOP (0.450 g; 0.865 mmol), N,N diisopropylethylamine (0.373 mL; 2.16 mmol) and 1-(4-acetylphenyl)-2-oxopyrrolidine-3-carboxylic acid (0.213 g; 0.865 mmol) in DMF (3 mL). Dichloromethane was added to the crude mixture to precipitate 1-(4-acetylphenyl)-N-(2-(5-chloro-1H-indol-3-yl)ethyl)-2-oxopyrrolidine-3-carboxamide 0.105 g (29%) as a solid.

Fuente