Reacción #86995

Ecuación de reacción

N,N diisopropylethylamine

2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride

2-oxo-1-(1-phenylethyl) pyrrolidine-3-carboxylic acid

PyBOP

→

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-2-oxo-1-(1-phenylethyl)pyrrolidine-3-carboxamide

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThis compound was prepared
2. 2
   OtroThe crude mixture was purified flash chromatography on silica (eluent 20 to 100% ethyl acetate in heptane)

Procedimiento

This compound was prepared according to method E with 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.100 g; 0.433 mmol), 2-oxo-1-(1-phenylethyl) pyrrolidine-3-carboxylic acid (0.101 g; 0.433 mmol), PyBOP (0.225 g; 0.433 mmol), N,N diisopropylethylamine (0.186 mL; 1.08 mmol) in DFM (3 mL). The crude mixture was purified flash chromatography on silica (eluent 20 to 100% ethyl acetate in heptane) to yield N-(2-(5-chloro-1H-indol-3-yl)ethyl)-2-oxo-1-(1-phenylethyl)pyrrolidine-3-carboxamide in two fractions (two sets of diastereoisomers) A 0.041 g (less polar fraction) and B 0.047 g (more polar fraction) (50% overall) as white solids.

Fuente