Reacción #86990

Ecuación de reacción

N,N diisopropylethylamine

2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride

1-(cyclohexylmethyl)-2-oxopyrrolidine-3-carboxylic acid

PyBOP

→

N-(2-(5-chloro-1H-indol-3-yl)ethyl)-1-(cyclohexylmethyl)-2-oxopyrrolidine-3-carboxamide

Rendimiento 38.4%

Disolventes

DMF

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThis compound was prepared
2. 2
   OtroThe crude mixture was purified flash chromatography on silica (eluent 20 to 100% ethyl acetate in heptane)

Procedimiento

This compound was prepared according to method E with 2-(5-chloro-1H-indol-3-yl)ethanamine hydrochloride (0.100 g; 0.433 mmol), 1-(cyclohexylmethyl)-2-oxopyrrolidine-3-carboxylic acid (0.097; 0.433 mmol), PyBOP (0.225 g; 0.433 mmol), N,N diisopropylethylamine (0.186 mL; 1.08 mmol) in dichloromethane (2 mL) and DMF (3 mL). The crude mixture was purified flash chromatography on silica (eluent 20 to 100% ethyl acetate in heptane) to yield 0.0668 g (38%) of N-(2-(5-chloro-1H-indol-3-yl)ethyl)-1-(cyclohexylmethyl)-2-oxopyrrolidine-3-carboxamide as a white solid.

Fuente