Reacción #8698

Ecuación de reacción

4,6-dichloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine

2-phenyl-ethanesulfonic acid amide potassium salt

→

2-phenyl-ethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide

Rendimiento 78.1%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroBulk of the solvent was evaporated before it
2. 2
   workup.ADDITIONwas diluted with diethyl ether (50 ml)
3. 3
   OtroThe precipitate that formed
4. 4
   Otrowas collected
5. 5
   Lavadowashed with diethyl ether (100 ml)
6. 6
   Otrodried

Procedimiento

A solution of 4,6-dichloro-5-(2-methoxyphenoxy)-2-(4-pyridyl)-pyrimidine (2 g) and 2-phenyl-ethanesulfonic acid amide potassium salt (2.82 g, Referential Example 1e) in DMF (50 ml) was stirred at rt for 16 h. Bulk of the solvent was evaporated before it was diluted with diethyl ether (50 ml). The mixture was acidified with 10% aq. citric acid. The precipitate that formed was collected, washed with diethyl ether (100 ml) and dried to give 2-phenyl-ethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide (2.23 g) as a beige powder. LC-MS: tR=4.93 min, [M+1]+=497.22, [M−1]−=494.96.

Fuente